Abstract
Novel, efficient synthetic pathways were developed for the synthesis of a variety of pyridazino-fused polycyclic ring systems not easily accessible by other routes. The strategy is based on the sequential or one-pot combinations of a palladium catalyzed C-C bond forming process (Suzuki or Heck-type reaction) and a C-X (X = N, O) or another C-C bond forming reaction (for C-X: nucleophilic substitution, condensation, lactonization, nitrene C-H insertion, Buchwald-Hartwig amination; for C-C: Pschorr reaction, Heck-type reaction). Some of these methodologies have also been extended to the preparation of several diazino-fused ring systems.
1 Introduction
2 Results
2.1 Suzuki Reaction of Halopyridazinones
2.2 Suzuki Reaction and Nitrene Insertion or Azo-Coupling
2.3 Suzuki Reaction and Nucleophilic Substitution or
2.4 Suzuki Reaction and Heck-Type Arylation
2.5 Suzuki Reaction and Pschorr Reaction
2.6 Nucleophilic Substitution Reaction and Heck-Type Arylation
2.7 Buchwald-Hartwig Reaction of Halopyridazinones
2.8 Buchwald-Hartwig Reaction and Heck-Type Arylation
3 Conclusion
4 References
Key words
pyridazine - palladium-catalyzed reaction - pyridazino-fused ring systems - diazino-fused ring systems
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