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Synlett 2004(6): 1120-1121
DOI: 10.1055/s-2004-822909
DOI: 10.1055/s-2004-822909
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York
Diazabicyclo[2.2.2]octane - DABCO
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
08. April 2004 (online)
Introduction
Diazabicyclo[2.2.2]octane, DABCO (I), is the most commonly used catalyst in the Baylis-Hillman reaction. [1] This important carbon-carbon bond forming reaction has received much attention in recent years because it provides multifunctional molecules with a newly created stereocenter, which are versatile building blocks in organic synthesis.
The generally accepted mechanism is illustrated in Scheme 1 for the DABCO-catalyzed Baylis-Hillman reaction of benzaldehyde with methyl acrylate.
Scheme 1 DABCO catalyzed Baylis-Hillman reaction
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