References
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1a For example, the dihydroxylation of alkenes: Kolb HC.
van Nieuwenhze MS.
Sharpless KB.
Chem. Rev.
1994,
94:
2483
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1b For the asymmetric alkoxy allylation of aldehydes, see: Hunt JA.
Roush WR.
J. Org. Chem.
1997,
62:
1112
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1c Catalytic enantioselective hydrolytic ring-opening of epoxides: Jacobsen EN.
Acc. Chem. Res.
2000,
33:
421
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For recent examples, see:
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2a
Carda M.
Falomir E.
Murga J.
Castillo E.
González F.
Marco JA.
Tetrahedron Lett.
1999,
40:
6845
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2b
Sasaki S.
Hamada Y.
Shioiri T.
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2c
Andrus MB.
Meredith EL.
Sekhar BVS.
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2d
Roush WR.
Pfeifer LA.
Marron TG.
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2e
Crimmins MT.
Choy AL.
J. Am. Chem. Soc.
1999,
121:
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3a
Kobayashi S.
Kawasuji T.
Synlett
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3b
Mukaiyama T.
Shiina I.
Uchiro H.
Kobayashi S.
Bull. Chem. Soc. Jpn.
1994,
67:
1708
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For examples of direct catalytic aldol reactions using α-oxygenated carbonyls, see:
-
4a
Notz W.
List B.
J. Am. Chem. Soc.
2000,
122:
7386
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4b
Trost BM.
Ito H.
Silcoff ER.
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3367
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4c
Yoshikawa N.
Suzuki T.
Shibasaki M.
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2002,
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2556
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For recent examples, see:
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5a
Ji J.
Barnes DM.
Zhang J.
King SA.
Wittenberger SJ.
Morton HE.
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1999,
121:
10215
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5b
Evans DA.
Downey CW.
Hubbs JL.
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125:
8706
- 6 For the use of α-carbonate substituted ketones and esters in palladium catalysed cyclopropanation, see: Ogoshi S.
Morimoto T.
Nishio K.
Ohe K.
Murai S.
J. Org. Chem.
1993,
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9
- 8
Willis MC.
Piccio VJ.-D.
Synlett
2002,
1625
- 11 (4R*,5S*)-4-Benzoyl-5-phenyl-[1,3]dioxolan-2-one is a known compound: Keshava Murthy KS.
Dhar DN.
J. Heterocycl. Chem.
1984,
21:
1721
7 Alternative Lewis acids such as Cu(OTf)2 and Sn(OTf)2 produced minimal reaction, while Zn(OTf)2 and Sc(OTf)3 resulted in complex reaction mixtures.
9 For a recent example of a Lewis acid catalysed process in which the addition of an external ligand was needed to achieve reaction, see ref. 5a.
10
General Procedure for the Direct Aldol Addition of Carbonates 1 to Aromatic Aldehydes: 4,4′-bipyridine (31.0 mg, 0.2 mmol), 4 Å molecular sieves (200 mg), and Mg(ClO4)2 (44.5 mg, 0.2 mmol) were stirred for 30 min in dry THF (2.5 mL) under a nitrogen atmosphere at ambient temperature. The suspension formed was then treated with the carbonate starting material (2 mmol) in THF (2.5 mL). After 10 min the aldehyde (1 mmol) and N-methyl-morpholine (0.055 mL, 0.5 mmol) were added dropwise. The reaction was monitored by thin layer chromatography. After 18-48 h the reaction mixture was filtered through celite and quenched with a saturated aqueous solution of NH4Cl (10 mL) and extracted with EtOAc (2 ¥ 30 mL). The organic layers were washed with a sat. aq solution of CuSO4 (10 mL) followed by H2O (30 mL) and brine (30 mL). The organic layer was dried (MgSO4) and concentrated in vacuo. The crude mixture of dioxolan-2-one diastereomers was purified by flash column chromatography on silica gel (50:1).
12 All new compounds were fully characterised. Selected data for novel compounds: (4
R
*,5
S
*)-4-Benzoyl-5-
p
-tolyl-[1,3]-dioxolan-2-one, colourless oil (259 mg, 92%). 1H NMR (300 MHz, CDCl3): δ = 7.92-7.99 (2 H, m, Ar-H), 7.63-7.70 (1 H, m, Ar-H), 7.47-7.55 (2 H, m, Ar-H), 7.24-7.35 (4 H, m, Ar-H), 5.92 [1 H, d, J = 6.3 Hz, Ph(C=O)CH], 5.59 (1 H, d, J = 6.3 Hz, ArCH), 2.40 (3 H, s, CH
3). 13C NMR (75 MHz, CDCl3): δ = 191.2, 153.2, 140.1, 135.0, 133.4, 132.7, 130.0, 129.4, 129.1, 126.1, 82.0, 79.1, 21.3. HRMS (ES+): C17H18NO4, [M + NH4]+ requires 300.1230. Found: 300.1227. (4
R
*,5
S
*)-4-Benzoyl-5-(4-methoxy-phenyl)-[1,3]-dioxolan-2-one, pale yellow oil (208 mg, 86%). 1H NMR (300 MHz, CDCl3): δ = 7.90-7.97 (2 H, m, Ar-H), 7.62-7.70 (1 H, m, Ar-H), 7.46-7.54 (2 H, m, Ar-H), 7.36 (2 H, d, J = 8.6 Hz, Ar-H), 6.97 (2 H, d, J = 8.6 Hz, Ar-H), 5.88 [1 H, d, J = 6.3 Hz, Ph(C=O)CH], 5.61 (1 H, d, J = 6.3 Hz, ArCH), 3.84 (3 H, s, OCH
3). 13C NMR (75 MHz, CDCl3): δ = 191.2, 160.9, 153.2, 134.9, 133.3, 129.3, 129.1, 127.9, 127.4, 114.8, 81.9, 79.2, 55.4. HRMS (ES+): C17H18NO5, [M + NH4]+ requires 316.1179. Found: 316.1181. (4
R
*,5
S
*)-4-Benzoyl-5-(4-trifluoromethyl-phenyl)-[1,3]-dioxolan-2-one, white solid (202 mg, 60%); mp 91-92 °C [from CH2Cl2/light petroleum (bp 40-60 °C)]. 1H NMR (400 MHz, CDCl3): δ = 7.97-8.04 (2 H, m, Ar-H), 7.65-7.77 (3 H, m, Ar-H), 7.50-7.62 (4 H, m, Ar-H), 6.16 [1 H, d, J = 6.5 Hz, Ph(C=O)CH], 5.49 (1 H, d, J = 6.5 Hz, ArCH). 13C NMR (75 MHz, CDCl3): δ = 191.0, 152.6, 139.7, 135.2, 133.9, 132.0 (q, 2
J
CF = 32.9 Hz), 129.6, 129.2, 126.4 (q, 3
J
CF = 3.8 Hz), 123.6 (q, 1
J
CF = 272.4 Hz), 81.9, 77.9. HRMS (ES+): C17H15F3NO4, [M + NH4]+ requires 354.0948. Found: 354.0945. (4
R
*,5
S
*)-4-(5-Benzoyl-2-oxo-[1,3]-dioxolan-4-yl)-benzonitrile, white solid (201 mg, 69%); mp 111 °C [from Et2O/light petroleum (bp 40-60 °C)]. 1H NMR (300 MHz, CDCl3): δ = 8.00-8.03 (2 H, m, Ar-H), 7.68-7.79 (3 H, m, Ar-H), 7.52-7.60 (4 H, m, Ar-H), 6.18 [1 H, d, J = 6.8 Hz, Ph(C=O)CH], 5.45 (1 H, d, J = 6.8 Hz, ArCH). 13C NMR (75 MHz, CDCl3): δ = 190.9, 152.3, 140.7, 135.3, 133.2, 133.1, 129.6, 129.2, 126.4, 117.9, 113.7, 81.8, 77.6. HRMS (ES+): C17H15N2O4, [M + NH4]+ requires 311.1026. Found: 311.1027. (4
R
*,5
S
*)-4-(Naphthalene-2-carbonyl)-5-phenyl-[1,3]-dioxolan-2-one, white solid (228 mg, 72%); mp 127 °C [from CH2Cl2/light petroleum (bp 40-60 °C)]. 1H NMR (400 MHz, CDCl3): δ = 8.41 (1 H, s, Ar-H), 7.88-8.04 (4 H, m, Ar-H), 7.56-7.69 (3 H, m, Ar-H), 7.47-7.57 (4 H, m, Ar-H), 6.05 [1 H, d, J = 6.2 Hz, Ar(C=O)CH], 5.74 (1 H, d, J = 6.2 Hz, PhCH). 13C NMR (75 MHz, CDCl3): δ = 191.0, 153.2, 136.3, 135.8, 132.2 × 2, 130.7, 130.0, 129.9, 129.7, 129.4, 129.2, 128.0, 127.4, 126.1, 123.9, 82.2, 79.2. HRMS (ES+): C20H18NO4, [M + NH4]+ requires 336.1230. Found: 336.1236. (4
R
*,5
S
*)-4-(Naphthalene-2-carbonyl)-5-
p
-tolyl-[1,3]-dioxolan-2-one, white solid (238 mg, 71%); mp 143-144 °C [from CH2Cl2/light petroleum (bp 40-60 °C)]. 1H NMR (300 MHz, CDCl3): δ = 8.40 (1 H, s, Ar-H), 7.86-8.04 (4 H, m, Ar-H), 7.56-7.70 (2 H, m, Ar-H), 7.27-7.38 (4 H, m, Ar-H), 5.98 [1 H, d, J = 6.3 Hz, Ar(C=O)CH], 5.73 (1 H, d, J = 6.3 Hz, ArCH), 2.41 (3 H, s, CH
3). 13C NMR (75 MHz, CDCl3): δ = 191.0, 153.3, 140.1, 136.3, 132.7, 132.2, 132.1, 130.7, 130.1, 129.9, 129.7, 129.2, 127.9, 127.3, 126.2, 123.9, 82.2, 79.3, 21.3. HRMS (ES+): C21H20NO4, [M + NH4]+ requires 350.1387. Found: 350.1384. (4
R
*,5
S
*)-4-(4-Methoxy-phenyl)-5-(naphthalene-2-carbonyl)-[1,3]-dioxolan-2-one, pale yellow solid (235 mg, 67%); mp 108 °C [from CH2Cl2/light petroleum (bp 40-60 °C)]. 1H NMR (300 MHz, CDCl3): δ = 8.38 (1 H, s, Ar-H), 7.86-8.04 (4 H, m, Ar-H), 7.56-7.70 (2 H, m, Ar-H), 7.36-7.42 (2 H, m, Ar-H), 6.96-7.02 (2 H, m, Ar-H), 5.93 [1 H, d, J = 6.9 Hz, Ar(C=O)CH], 5.75 (1 H, d, J = 6.9 Hz, ArCH), 3.85 (3 H, s, OCH
3). 13C NMR (75 MHz, CDCl3): δ = 191.0, 160.9, 153.3, 136.3, 132.2, 132.1, 130.7, 129.9, 129.7, 129.2, 128.0, 127.9, 127.4 × 2, 123.9, 114.8, 82.1, 79.4, 55.5. HRMS (ES+): C21H20NO5, [M + NH4]+ requires 366.1336. Found: 366.1337. (4
R
*,5
S
*)-4-(Naphthalene-2-carbonyl)-5-(4-trifluoromethyl-phenyl)-[1,3]-dioxolan-2-one, white solid (669 mg, 87%); mp 133 °C [(from CH2Cl2/light petroleum (bp 40-60 °C)]. 1H NMR (300 MHz, CDCl3): δ = 8.50 (1 H, s, Ar-H), 8.01-8.07 (1 H, m, Ar-H), 7.88-7.98 (3 H, m, Ar-H), 7.57-7.77 (6 H, m, Ar-H), 6.22 [1 H, d, J = 6.5 Hz, Ar(C=O)CH], 5.64 (1 H, d, J = 6.5 Hz, ArCH). 13C NMR (75 MHz, CDCl3): δ = 190.8, 152.7, 139.7, 136.4, 132.4, 132.2, 132.0 (q, 2
J
CF = 32.9 Hz), 130.6, 130.0, 129.8, 129.2, 128.0, 127.5, 126.4 (q, 3
J
CF = 3.7 Hz), 126.3 × 2, 123.7 (q, 1
J
CF = 273.1 Hz), 123.9, 82.0, 78.0. HRMS (ES+): C21H17F3NO4, [M + NH4]+ requires 404.1104. Found: 404.1100. (4
R
*,5
S
*)-4-[5-(Naphthalene-2-carbonyl)-2-oxo-[1,3]-dioxolan-4-yl]-benzonitrile, white solid (467 mg, 68%); mp 147 °C (from CH2Cl2). 1H NMR (300 MHz, CDCl3): δ = 8.53 (1 H, s, Ar-H), 7.89-8.07 (4 H, m, Ar-H), 7.76-7.80 (2 H, m, Ar-H), 7.66-7.72 (1 H, m, Ar-H), 7.58-7.66 (3 H, m, Ar-H), 6.25 [1 H, d, J = 6.9 Hz, Ar(C=O)CH], 5.59 (1 H, d, J = 6.9 Hz, ArCH). 13C NMR (75 MHz, CDCl3): δ = 190.7, 152.4, 140.8, 136.4, 133.1, 132.6, 132.2, 130.6, 130 × 2, 129.3, 128.0, 127.5, 126.4, 123.9, 117.9, 113.8, 82.0, 77.7. HRMS (ES+): C21H17N2O4, [M + NH4]+ requires 361.1183. Found: 361.1184.
13 These observations are based on the isolation of the individual diastereomeric aldol adducts and cyclic carbonates and resubjection of these components to the reaction conditions.
14 For Baeyer-Villiger reactions on similar compounds, see ref. 4c.
15 Baeyer-Villiger oxidation of the phenyl ketone produced an 8:1 mixture of regioisomers, with the desired phenyl ester predominating.