Subscribe to RSS
DOI: 10.1055/s-2004-822942
© Georg Thieme Verlag Stuttgart · New York
Pro und Contra der pelvinen Lymphadenektomie beim Prostatakarzinom
Publication History
Publication Date:
15 July 2004 (online)
Der Stellenwert der pelvinen Lymphadenektomie (LA) als Stagingmaßnahme im Rahmen der radikalen Prostatektomie beim Prostatakarzinom (PCA) wird in der Literatur noch immer kontrovers diskutiert. Während einige Autoren auf der Basis von präoperativen Nomogrammen die pelvine Lymphadenektomie nur bei Patienten mit einem hohen Metastasierungsrisiko befürworten, favorisieren andere aufgrund der fehlenden individuellen Verlässlichkeit der Nomogramme die Lymphadenektomie als generelle operative Maßnahme. Erfolgt die pelvine Lymphadenektomie ist die Frage zu klären, ob diese im Sinne der limitierten oder der extendierten Variante erfolgen sollte.
Literatur
- 1 Gil-Vernet JM.. Prostate cancer: anatomical and surgical considerations. Brit J Urol. 1996; 78 161-168
- 2 Crawford ED.. Batuello JT.. Snow P.. Gamito EJ.. McLeod DG.. Stone N.. Montie J.. Stock R.. Lynch J.. Brandt J.. The use of artificial intelligence technology to predict lymph node spread in men with clinically localized prostate carcinoma. Cancer. 2000; 88 2105-2109
- 3 Batuello JT.. Gamito EJ.. Crawford ED.. Han M.. Partin AW.. McLeod DG.. Artificial neural network model for the assessment of lymph node spread in patients with clinically localized prostate cancer. Urology. 2001; 57 481-485
- 4 Partin AW.. Kattan MW.. Subing ENP.. Walsh PC.. Wojno KJ.. Oesterling JE.. Combination of prostate-specific antigen, clinical stage, and Gleason sum to predict pathological stage of localized prostate cancer: a multi-institutional update. JAMA. 1997; 277 1445-1451
- 5 Algari M.. Colton MD.. Seidmon ED.. Greenberg RE.. Hanno PM.. The staging pelvic lymphadenectomy: implication as an adjunctive procedure for clinically localized prostate cancer. J Urol. 1997; 162 243-246
- 6 Bader P.. Burkhard FC.. Markwalder R.. Studer UE.. Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a hance of cure?. J Urol. 2003; 169 849-854
- 7 Heidenreich A.. von Knobloch R.. Varga Z.. Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy in prostate cancer: high incidence of lymph node metastases. J Urol. 2001; 167 1681-1684
- 8 Heidenreich A.. von Knobloch R.. Varga Z.. Hofmann R.. Extended pelvic lymphadenectomy in men undergoing radical retropubic prostatectomy - data on > 300 cases. J Urol. 2004;
- 9 Weingärtner K.. Ramaswamy A.. Bittinger A.. Gerharz EW.. Vöge D.. Riedmiller H.. Anatomical basis for pelvic lymphadenectomy in prostate cancer: results of an autopsy study and implications for the clinic. J Urol. 1996; 156 1969-1971
- 10 Cheng L.. Zincke H.. Blute ML.. Bergstralh EJ.. Scherer B.. Bostwick DG.. Risk of prostate cancer death in patients with lymph node metastasis. Cancer. 2001; 91 66-71
- 11 Hull HW.. Rabbani F.. Abbas F.. Wheeler TM.. Kattan MW.. Scardino PT.. Cancer control with radical prostatectomy alone in 1000 consecutive patients. J Urol. 2002; 167 528-534
- 12 Narayan P.. Fournier G.. Gajendran V.. Leidich R.. Lo R.. Wolf JS.. Jacob G.. Nicolaisen G.. Palmer K.. Freiha F.. Utility of preoperative serum prostate specific antigen concentration and biopsy Gleason score in predicting risk of pelvic lymph node metastases in prostate cancer. Urology. 1994; 44 519-524
- 13 Bluestein DL.. Bostwick DG.. Bergstralh EJ.. Oesterling JE.. Eliminating the need for bilateral pelvic lymphadenectomy in select patients with prostate cancer. J Urol. 1994; 151 1315-1320
- 14 Conrad S.. Graefen M.. Pichlmaier U.. Henke RP.. Hammerer PG.. Huland H.. Systematic sextant biopsies improve preoperative prediction of pelvic lymph node metastasis in patients with clinically localized prostate cancer. J Urol. 1998; 159 2023
- 15 Conrad S.. Graefen M.. Pichlmaier U.. Henke RP.. Ebersdobler A.. Hammerer PG.. Huland H.. Prospective validation of an algoithm with systematic sextant biopsy to predict lymph node metastasis in patients with clinically localized prostate cancer. J Urol. 2002; 167 521
- 16 Haese A.. Epstein JI.. Huland H.. Partin PW.. Validation of a biopsy based pathologic algorithm for predicting lymph node metastases in patients with clinically localized prostatic carcinoma. Cancer. 2002; 95 1016
- 17 Naya Y.. Babaian RJ.. The predictors of pelvic lymph node metastasis at radical retropubic prostatectomy. J Urol. 2003; 170 2306-2310
- 18 Gervasi LA.. Mata J.. Easley JD.. Wilbanks JH.. Seale-Hawkins C.. Carlton Jr. CE. Scardino PT.. Prognostic significance of lymph nodal metastases in prostate cancer. J Urol. 1989; 142 332-336
- 19 Dillioglugil JF.. Leibman BD.. Leibman NS.. Kattan MW.. Rosas AL.. Scardino PT.. Risk factors for complications and morbidity after radical retropubic prostatectomy. J Urol. 1997; 157 1760-1767
- 20 Fergany A.. Kupelian PA.. Levin HS.. Zippe CD.. Reddy C.. Klein EA.. No difference in biochemical failure reates with or without pelvic lymph node dissection during radical prostatectomy in low-risk patients. Urology. 2000; 56 92-95
- 21 Meng MV.. Carroll PR.. When is pelvic lymph node dissection necessary before radical prostatectomy? A decision analysis. J Urol. 2000; 164 1235-1240
- 22 El-Galley RES.. Keane TE.. Petros JA.. Sanders WH.. Clarke HS.. Cotsonis GA.. Graham SD.. Evaluation of staging lymphadenectomy in prostate cancer. Urology. 1998; 52 663-667
- 23 Jakse G.. Brehmer B.. Wolf JM.. Aretz R.. Handt S.. Die radikale perineale Prostatektomie ohne Lymphadenektomie. Urol A. 1999; 38 143-149
- 24 Wawroschek F.. Vogt H.. Weckermann D.. Wagner Th.. Harzmann R.. Radioisotope guided pelvic lymph node dissection for prostate cancer. J Urol. 2001; 38 1715-1719
- 25 Polasczik TJ.. Manyak MJ.. Haseman MK.. Gurganus RT.. Rogers B.. Maguire RT.. Partin AW.. Comparison of clinical staging algorithms and 111Indium-Capromab Pendetide Immunoscintigraphy in the prediction of lymph node involvement in high risk prostate carcinoma patients. Cancer. 1999; 85 1586-1592
- 26 Sodee DB.. Malguria N.. Faulhaber P.. Resnick MI.. Albert J.. Bakale G.. and the Prostacint Imaging Centers. Multicenter Prostacint imaging findings in 2154 patients with prostate cancer. Urology. 2000; 56 988-993
Prof. Dr. med. A. HeidenreichLeiter, Bereich für Urologische Onkologie
Sektion für Urologische Onkologie, Klinik und Poliklinik für Urologie, Medizinische Einrichtungen der Universität zu Köln,
Joseph-Stelzmann-Str. 9
50924 Köln
Email: ab.heidenreich@web.de