Platelet Anti-Aggregating Triterpenoids from the Leaves of Acanthopanax senticosus and the Fruits of A. sessiliflorus

Jing Ling Jin; Sanghyun Lee; Yong Yook Lee; Jeong Mi Kim; Jung Eun Heo; Hye Sook Yun-Choi

doi:10.1055/s-2004-827159

Planta Medica, Table of Contents

Planta Med 2004; 70(6): 564-566
DOI: 10.1055/s-2004-827159

Letter

Platelet Anti-Aggregating Triterpenoids from the Leaves of Acanthopanax senticosus and the Fruits of A. sessiliflorus

Jing Ling Jin¹ ^, ² , Sanghyun Lee¹ , Yong Yook Lee¹ , Jeong Mi Kim¹ , Jung Eun Heo¹ , Hye Sook Yun-Choi¹

¹Natural Products Research Institute, Seoul National University, Seoul, Korea
²On leave from Yanbian University, College of Medicine, Yanji, P.R. China

The authors are grateful for the financial support of the Korea Health 21 R&D Project, the Ministry of Health and Welfare (01-PJ2-PG6-01NA01-0002), Republic of Korea

Abstract

Six triterpenoids, chiisanogenin, chiisanoside, ursolic acid, oleanolic acid, β-sitosterol and daucosterol, were isolated as the platelet anti-aggregating components from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus. Chiisanogenin showed about 50-fold higher potency than acetylsalicylic acid (ASA) on U46619-induced platelet aggregation (IC₅₀: 6.21 μM) and 10 - 20-fold higher effects than ASA on epinephrine- and arachidonic acid (AA)-induced aggregation (IC₅₀: 2.50 and 4.81 μM, respectively).

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Prof. Hye Sook Yun-Choi

Natural Products Research Institute

Seoul National University

Seoul 110-460

Korea

Phone: +82-2-740-8923

Fax: +82-2-766-7818

Email: hsyun@snu.ac.kr