Abstract
Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.
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Dr. Jong Seog Ahn
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
52 Eoeun-dong
Yusong
Taejeon 305-333
Korea
Fax: +82-42-860-4595
Email: jsahn@kribb.re.kr
