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Synthesis 2004(15): 2586-2590
DOI: 10.1055/s-2004-829188
DOI: 10.1055/s-2004-829188
PSP
© Georg Thieme Verlag Stuttgart · New York
Synthesis and Use of a Phosphoramidite Ligand for the Copper-Catalyzed Enantioselective Allylic Substitution. Tandem Allylic Substitution/Ring-Closing Metathesis
Further Information
Received
26 April 2004
Publication Date:
30 July 2004 (online)
Publication History
Publication Date:
30 July 2004 (online)
Abstract
A new one-pot method of reductive amination is used to prepare a chiral C2 symmetrical amine. This amine is used for the synthesis of a new chiral phosphoramidite ligand. The new ligand is, in turn, used to illustrate the enantioselective copper-catalyzed allylic substitution with Grignard reagents. When a remote double bond is located on the Grignard reagent, the newly formed alkene undergoes an in situ ruthenium-catalyzed ring-closing metathesis to afford the cyclized product in 77% yield and 94% ee.
Key words
allylic substitution - copper catalysis - ruthenium catalysis - enantioselectivity - Grignard reagents
- 1
Magid RM. Tetrahedron 1980, 36: 1901 - 2
Trost BM.van Vranken DL. Chem. Rev. 1996, 96: 395 -
3a
Posner GH. Org. React. 1975, 22: 253 -
3b
Lipshutz BH.Sengupta S. Org. React. 1992, 41: 135 - 4
Karlström ASE.Bäckvall J.-E. In Modern Organocopper ChemistryKrause N. Wiley-VCH; Weinheim: 2001. p.259-288 -
5a
van Klaveren M.Persson ESM.del Villar A.Grove DM.Bäckvall J.-E.van Koten G. Tetrahedron Lett. 1995, 36: 3059 -
5b
Karlstrom ASE.Huerta FF.Meuzelaar GJ.Bäckvall J.-E. Synlett 2001, 923 -
6a
Dubner F.Knochel P. Angew. Chem. Int. Ed. 1999, 38: 379 -
6b
Dubner F.Knochel P. Tetrahedron Lett. 2000, 41: 9233 -
7a
Luchaco-Cullis CA.Mizutani H.Murphy KE.Hoveyda AH. Angew. Chem. Int. Ed. 2001, 40: 1456 -
7b
Malda H.van Zijl AW.Arnold LA.Feringa BL. Org. Lett. 2001, 3: 1169 -
7c
Ongeri S.Piarulli U.Roux M.Monti C.Gennari C. Helv. Chim. Acta 2002, 85: 3388 -
7d
Piarulli U.Daubos P.Claverie C.Roux M.Gennari C. Angew. Chem. Int. Ed. 2003, 42: 234 -
7e
Murphy KE.Hoveyda AH. J. Am. Chem. Soc. 2003, 125: 4690 -
7f
Piarulli P.Claverie C.Daubos P.Gennari C.Minnaard AJ.Feringa BL. Org. Lett. 2003, 5: 4493 -
7g
Shi W.-J.Wang L.-X.Fu Y.Zhu S.-F.Zhou Q.-L. Tetrahedron: Asymmetry 2003, 14: 3867 -
7h
van Zijl AW.Arnold LA.Minnaard AJ.Feringa BL. Adv. Synth. Catal. 2004, 346: 413 -
8a
Alexakis A.Malan C.Lea L.Benhaim C.Fournioux X. Synlett 2001, 927 -
8b
Alexakis A.Croset K. Org. Lett. 2002, 4: 4147 -
8c
Tissot-Croset K.Polet D.Alexakis A. Angew. Chem. Int. Ed. 2004, 43: 2426 - 9
Alexakis A.Gille S.Prian F.Rosset S.Ditrich K. Tetrahedron Lett. 2004, 45: 1449 - 10
Overberger CG.Marullo NP.Hiskey RG. J. Am. Chem. Soc. 1961, 83: 1374 - 11
Storace L.Anzalone L.Confalone P.Davis WP.Fortynak JM.Giangiordano M.Haley JJ.Kambolz K.Li H.-Y.Ma P.Nugent WA.Parsons RL.Sheeran PJ.Silverman CE.Waltermire RE.Wood CC. Org. Process Res. Dev. 2002, 6: 54 - 12
Trnka TM.Grubbs RH. Acc. Chem. Res. 2001, 34: 18 -
13a
Saudan LA.Bernardinelli G.Kundig EP. Synlett 2000, 483 -
13b
This compound is available from BASF AG on the following website: http://www.basf.de/en/produkte/chemikalien/interm/.
- 14
Watson SC.Eastham JF. J. Organomet. Chem. 1967, 9: 165 - 15
Gilbertson SR.Fu Z. Org. Lett. 2001, 3: 161 - 16 CuTC can either be purchased from Frontier Scientific Ltd or prepared according to the literature procedure:
Allred GD.Liebeskind LS. J. Am. Chem. Soc. 1996, 118: 2748