Sulphamic Acid - An Efficient and Cost-Effective Solid Acid Catalyst for the Pechmann Reaction

Pankajkumar R. Singh; Devendrapratap U. Singh; Shriniwas D. Samant

doi:10.1055/s-2004-830858

LETTER

Sulphamic Acid - An Efficient and Cost-Effective Solid Acid Catalyst for the Pechmann Reaction

Pankajkumar R. Singh, Devendrapratap U. Singh, Shriniwas D. Samant*
Organic Chemistry Research Laboratory, University Institute of Chemical Technology, N. M. Parekh Marg, Matunga, Mumbai-400 019, India
Fax: +91(22)24145614; e-Mail: samantsd@udct.org;

Abstract

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Abstract

Sulphamic acid (H₂NSO₃H, SA) is used as an alternative to conventional acid catalysts in the Pechmann condensation of phenols with β-ketoester leading to the formation of substituted coumarin. The method is simple, cost-effective, solvent-free and gives good yields in a short reaction time.

Key words

sulphamic acid - Pechmann reaction - coumarins

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References

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Typical Experimental Procedure: To the weighed quantity of phenol (10 mmol), and β-keto ester (10 mmol), the sulphamic acid (5 mmol) was added and the reaction mixture was stirred at 130 °C in a pre-heated oil-bath. After completion of the reaction at the desired time as indicated in Table [1] , the reaction mixture was poured into water and the resultant product was filtered. The products were further purified by column chromatography. The compounds are well known and in agreement with spectral and physical data.