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Synthesis 2004(15): 2471-2478  
DOI: 10.1055/s-2004-831204
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Ferrocenyl-1-(4-pyridylmethyl)- and Ferrocenyl-1-[2-hydroxy-1,2-bis(4-pyridyl)ethyl]pyrazoles

Eduardo A. Vázquez Lópeza, Elena I. Klimova*a, Tatiana Klimovaa, Cecilio Alvarez Toledanob, Lena Ruíz Ramíreza, Ruben Alfredo Toscanob, Marcos Martínez Garcíab
a Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, C.P. 04510, México D.F., México
b Instituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, C.P. 04510, México D.F., México
Fax: +52(5)556225371; e-Mail: klimova@servidor.unam.mx;
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Publikationsverlauf

Received 9 April 2004
Publikationsdatum:
02. September 2004 (online)

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Abstract

Pyridine-4-carbaldehyde reacts with ferrocenyl-4,5-dihydropyrazoles to yield ferrocenyl-1-(4-pyridylmethyl)pyrazoles and ferrocenyl-1-[2-hydroxy-1,2-bis(4-pyridyl)ethyl]pyrazoles. The structures of the compounds obtained were established based on spectroscopic (IR, mass, 1H and 13C NMR) data. X-ray diffraction data for 4-[3-(p-bromophenyl)-5-ferrocenyl-1-(4-pyridyl)-methylpyrazole­ corroborate its structure.

Key words

α,β-unsaturated ketones - ferrocenylpyrazolines - ferrocenyl-1-(4-pyridylmethyl)pyrazoles - ferrocenyl-1-[2-hydroxy-1,2-bis(4-pyridyl)ethyl]pyrazoles

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