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DOI: 10.1055/s-2004-832610
© Georg Thieme Verlag KG Stuttgart · New York
Prenylated Indole Alkaloids from Flustra foliacea with Subtype Specific Binding on NAChRs
Publication History
Received: February 23, 2004
Accepted: July 26, 2004
Publication Date:
18 October 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200410/lookinside/thumbnails/10.1055-s-2004-832610-1.jpg)
Abstract
Several brominated indole alkaloids and a diterpene (1 - 7) were isolated from the dichloromethane extract of the North Sea Bryozoan Flustra foliacea. Alkaloid 4 is a new natural product, whose structure was elucidated by interpretation of spectroscopic data (NMR, mass, UV, and IR). All compounds were tested for their in vitro affinity towards the α4ß2* and α7* subtype of the neuronal nicotinic acetylcholine receptor (nAChR) using radioligand binding assays. Deformylflustrabromine (3) and deformylflustrabromine B (4) were shown to have affinities in the lower micromolar range for nAChRs, differing in their subtype preference.
Key words
Flustra foliacea - alkaloids - nicotinic acetylcholine receptors
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Prof. Dr. Gabriele M. König
Institute for Pharmaceutical Biology
University of Bonn
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