Neonates are at increased risk of injury from infiltration of intravenous fluids because
of small vessel size and immature skin structure. Until recently, hyaluronidase injection
was used to prevent tissue injury following the infiltration of intravenous solutions
in neonates. The production of hyaluronidase injection was discontinued in 2001. The
alternative, compounded hyaluronidase injection is not regulated by the U.S. Food
and Drug Administration and is subject to variation in quality assurance practices.
Amorphous hydrogels have been used as wound dressings for sloughy or necrotic wounds
in a variety of clinical settings. Hydrogels facilitate autodebridement of the wound
by rehydrating slough and enhancing the rate of autolysis. No adverse effects or increased
infection rates have been associated with the use of hydrogel dressings. DuoDerm Hydroactive
gel is a sterile, preservative-free, viscous, hydrating gel composed of natural hydrocolloids.
We report our experience using DuoDerm Hydroactive gel for management of injury secondary
to the infiltration of total parenteral nutrition solution and lipid emulsion in three
neonates.
KEYWORDS
Infiltration - hydrogel - neonates
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