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Am J Perinatol 2004; 21(7): 409-414
DOI: 10.1055/s-2004-835309
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Management of Infiltration Injury in Neonates Using DuoDerm Hydroactive Gel

Victoria Tutag Lehr1 , Marianne Lulic-Botica2 , William J. Lindblad3 , Nadya J. Kazzi4 , J. V. Aranda5
  • 1Associate Professor, Pharmacy Practice, The Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, Michigan
  • 2Clinical Pharmacy Specialist, Hutzel Women’s Hospital, The Detroit Medical Center, Detroit, Michigan
  • 3Associate Professor, Pharmaceutical Sciences, The Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, Michigan
  • 4Associate Professor, Pediatrics, Wayne State University, Detroit, Michigan
  • 5Professor of Pediatrics, Pharmacology, Pharmaceutical Sciences, Wayne State University, and Chief, Clinical Pharmacology & Toxicology, Children’s Hospital of Michigan, Detroit, Michigan
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Publication History

Publication Date:
08 October 2004 (online)

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Neonates are at increased risk of injury from infiltration of intravenous fluids because of small vessel size and immature skin structure. Until recently, hyaluronidase injection was used to prevent tissue injury following the infiltration of intravenous solutions in neonates. The production of hyaluronidase injection was discontinued in 2001. The alternative, compounded hyaluronidase injection is not regulated by the U.S. Food and Drug Administration and is subject to variation in quality assurance practices. Amorphous hydrogels have been used as wound dressings for sloughy or necrotic wounds in a variety of clinical settings. Hydrogels facilitate autodebridement of the wound by rehydrating slough and enhancing the rate of autolysis. No adverse effects or increased infection rates have been associated with the use of hydrogel dressings. DuoDerm Hydroactive gel is a sterile, preservative-free, viscous, hydrating gel composed of natural hydrocolloids. We report our experience using DuoDerm Hydroactive gel for management of injury secondary to the infiltration of total parenteral nutrition solution and lipid emulsion in three neonates.

KEYWORDS

Infiltration - hydrogel - neonates

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Victoria Tutag LehrPharm.D. 

Department of Pharmacy Practice, The Eugene Applebaum College of Pharmacy & Health Sciences

Wayne State University, Detroit, MI 48201