Solid-Phase Synthesis of a Double 4-Pyridinyl Terminated Leu-Ala-Leu Tripeptide and Macrocyclization by Palladium(II) Coordination

Markus Albrecht; Patrick Stortz; Marianne Engeser; Christoph A. Schalley

doi:10.1055/s-2004-835624

LETTER

Solid-Phase Synthesis of a Double 4-Pyridinyl Terminated Leu-Ala-Leu Tripeptide and Macrocyclization by Palladium(II) Coordination

Markus Albrecht*^a, Patrick Stortz^a, Marianne Engeser^b, Christoph A. Schalley^b
^a Institut für Organische Chemie der RWTH-Aachen, Professor-Pirlet-Strasse 1, 52074 Aachen, Germany
^b Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany
Fax: +49(241)8092385; e-Mail: markus.albrecht@oc.rwth-aachen.de;

Abstract

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Abstract

A Leu-Ala-Leu tripeptide, which bears pyridinyl units at the N- as well as C-terminus, is prepared by combination of solid- and solution-phase synthesis. With the Pd(en)²⁺ fragment it forms a mixture of 1:1 and 2:2 complexes, with the mononuclear complex probably being the dominating species.

Key words

solid-phase - coupling - pyridines - peptides - macrocycles

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References

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