Prevention and Treatment of Central Nervous System Involvement by Non-Hodgkin's Lymphoma: A Review of the Literature

Natalia Colocci; Michael Glantz; Lawrence Recht

doi:10.1055/s-2004-861534

Seminars in Neurology, Inhaltsverzeichnis

Semin Neurol 2004; 24(4): 395-404
DOI: 10.1055/s-2004-861534

Prevention and Treatment of Central Nervous System Involvement by Non-Hodgkin's Lymphoma: A Review of the Literature

Natalia Colocci¹ , Michael Glantz³ , Lawrence Recht²

¹Department of Medical Oncology, Stanford University Medical Center, Palo Alto, California
²Department of Neurology, Stanford University Medical Center, Palo Alto, California
³Department of Neurology, University of Massachusetts Medical Center, Pittsfield, Massachusetts

Abstract

ABSTRACT

Direct invasion of the central nervous system (CNS) occurs in 5% of all patients with non-Hodgkin's lymphoma, either at the time of presentation, as a solitary site of relapse, or during the course of progressive disease. Over the last several years, several studies, mostly retrospective, have analyzed risk factors associated with this complication as well as various methods to both treat and prevent it. A systematic review of the literature reveals that although a profile of a patient at particularly high risk for developing disease can be identified, treatments are for the most part ineffective at improving survival in patients with CNS lymphoma, and there is no high-quality evidence that prophylaxis prevents its occurrence. A randomized controlled trial to assess the value of prophylaxis in this disease is warranted, and suggestions for how such a trial might be designed are included in this review.

KEYWORDS

Leptomeningeal lymphoma - CNS prophylaxis - intraventricular

Volltext

Referenzen

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Lawrence RechtM.D.

Department of Neurology, Stanford University Medical Center

300 Pasteur Drive, Palo Alto, CA 94305

Ann Arbor, MI 48109-0311