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DOI: 10.1055/s-2005-837771
Reduction of Side Effects by Combining Clozapine with Amisulpride: Case Report and Short Review of Clozapine-Induced Hypersalivation
A Case ReportPublikationsverlauf
Received: 9.5.2004
Revised: 13.5.2004
Accepted: 8.6.2004
Publikationsdatum:
11. Februar 2005 (online)
Side effects from a high-dose clozapine treatment for a schizophrenic patient led to massive compliance problems. The dose of clozapine could be halved without recurrence of an acute psychotic symptomatology by concomitantly administering amisulpride. The side effects, especially hypersalivation, disappeared almost entirely, which in turn led to good compliance. In a short review we would like to present the pathophysiology and therapeutic options of clozapine-induced hypersalivation.
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Dr. Bernhard Croissant, MD
Department of Addictive Behavior and Addiction Medicine
Central Institute of Mental Health
University of Heidelberg
J 5
68159 Mannheim
Telefon: +49 621 1703 3502
Fax: +49 621 1703 1205
eMail: croissant@zi-mannheim.de