Synthesis of a Cyclen-Functionalized α-Amino Acid and its Incorporation into Peptide Sequence

Shan-Yong Chen; Yu Huang; Guo-Lin Zhang; Hua Cheng; Chuan-Qin Xia; Li-Jian Ma; Hong Yu; Xiao-Qi Yu

doi:10.1055/s-2005-861854

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Synthesis of a Cyclen-Functionalized α-Amino Acid and its Incorporation into Peptide Sequence

Shan-Yong Chen^a, Yu Huang^a, Guo-Lin Zhang^b, Hua Cheng^a, Chuan-Qin Xia^a, Li-Jian Ma^a, Hong Yu^a, Xiao-Qi Yu*^a
^a Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu 610064, P. R. China
^b Chengdu Institute of Biology, The Chinese Academy of Sciences, Chengdu 610041, P. R. China
Fax: +86(28)85415886; e-Mail: schemorg@mail.sc.cninfo.net;

Abstract

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Abstract

A cyclen-functionlized α-amino acid was obtained through embedding cyclen into the side chain of homoserine. The α-amino acid can be conveniently incorporated into peptide sequence to form new ligands, which have strong coordination ability for transition metal ions.

Key words

cyclen - unnatural amino acid - metallopeptides

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References

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