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DOI: 10.1055/s-2005-862383
Recent Progress in the Synthesis of Morphine Alkaloids
Publication History
Publication Date:
04 February 2005 (online)
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Abstract
Recent accomplishments in the field of total synthesis of morphine alkaloids are reviewed. Approaches to the skeleton of morphine are included as are various efforts towards related medicinally important agents. The literature coverage begins after the publication of our last update in 2000 and continues mid-way through 2004.
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1 Introduction
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2 Total Syntheses of Morphine
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2.1 Taber
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2.2 Trost
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2.3 Ogasawara
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3 Approaches to the Morphine Skeleton
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3.1 Vollhardt
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3.2 Ogasawara
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3.3 Cheng
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3.4 Passarella
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3.5 Hudlicky
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3.6 Hudlicky
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4 Unnatural Analogs and Mimics
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4.1 Rice
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4.2 Grauert
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4.3 Trost
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4.4 Ohno
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4.5 Schmidhammer
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5 Conclusions and Outlook
Key words
morphine - total synthesis - alkaloids - approaches to morphine skeleton - morphine analogs and mimics
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Santos, L.; Finn, K.; Koroniak, L.; Hudlicky, T. unpublished observations.