Cu(I)-Catalyzed Cyclized Coupling Reaction of o-Ethynylphenylphosphonic Acid Monoesters with Allyl Bromide

Abstract

4-Allylphosphaisocoumarins can be prepared in good yield and with high regioselectivity by the reaction of o-ethynyl­phenylphosphonic acid monoesters with allyl bromide catalyzed by CuI. The present reaction represents the first example of a phosphonic acid monoester cyclized coupling reaction with alkyl halide.

Key words

phosphaisocoumarin - bioactivity - o-ethynylphenylphosphonic acid monoester - cyclization - coupling

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