Synthesis of 2,4,5-Trisubstituted Oxazoles

Xiao-hua Cai; Hai-jun Yang; Guo-lin Zhang

doi:10.1055/s-2005-865360

SHORTPAPER

Synthesis of 2,4,5-Trisubstituted Oxazoles

Xiao-hua Cai^a,b, Hai-jun Yang^a, Guo-lin Zhang*^a
^a Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu 610041, P. R. China
Fax: +86(28)85225401; e-Mail: ZHANGGL@cib.ac.cn;
^b Chengdu Institute of Organic Chemistry, the Chinese Academy of Sciences, Chengdu 610041, P. R. China

Abstract

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Abstract

2,4,5-Trisubstituted oxazoles were synthesized in good yields starting from α-methylene ketones by nitrosation, condensation with aldehydes and reduction with zinc in acetic acid at 40 °C. (5-Methyl-2-phenyloxazol-4-yl)ethanol was prepared by reduction of ethyl (5-methyl-2-phenyloxazol-4-yl)acetate with LiAlH₄.

Key words

oxazole - 2,4,5-trisubstituted oxazole - (5-methyl-2-phenyloxazol-4-yl)ethanol - α-diketone monooxime - condensation

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References

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