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Synfacts 2005(0): 0030-0030
DOI: 10.1055/s-2005-865377
DOI: 10.1055/s-2005-865377
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Ru-Catalyzed ortho-Selective Direct Cross-Coupling Reaction of 2-Aryloxazolines and 2-Arylimidazolines
S. Oi*, E. Aizawa, Y. Ogino, Y. Inoue*
Tohoku University, Japan
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
A ruthenium(II)-phosphine complex has been shown to catalyze direct coupling of 2-aryloxazolines and 2-arylimidazolines with aryl and alkenyl halides to give regioselectively 2- and 2,6-substituted products in moderate to excellent yields. Coupling of 3-substituted phenyloxazolines and N-acylarylimidazolines with aryl or vinyl halides give 2-substituted derivatives as the only products. The known conversion of oxazolinyl and imidazolinyl groups to other functionalities offers a further advantage of this methodology.