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Synlett 2005(9): 1456-1458
DOI: 10.1055/s-2005-868511
DOI: 10.1055/s-2005-868511
LETTER
© Georg Thieme Verlag Stuttgart · New York
Direct Oxidative Conversion of Primary Alcohols to Nitriles Using Molecular Iodine in Ammonia Water
Weitere Informationen
Received
23 March 2005
Publikationsdatum:
29. April 2005 (online)
Publikationsverlauf
Publikationsdatum:
29. April 2005 (online)
![](https://www.thieme-connect.de/media/synlett/200509/lookinside/thumbnails/10.1055-s-2005-868511-1.jpg)
Abstract
A simple, effective, high-yield procedure for the direct oxidative conversion of alcohols to nitriles, was successfully carried out with molecular iodine in ammonia water.
Key words
molecular iodine - oxidation - alcohol - nitrile - ammonia water
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References
CAUTION: It is known that iodine reacts with ammonia water under certain conditions to give a black powder of nitrogen triiodide monoamine (NI3·NH3). The dry powder explodes readily by mechanical shock, heat or irradiation. Although we did not have any incidents in this study, one should be careful.
14Online data from Sigma-Aldrich products;
http://www.sigmaaldrich.com/Brands/Aldrich.html