Insulin-like Growth Factor Binding Protein-1 Detection in Preterm Labor: Evaluation of a Bedside Test

Shai E. Elizur; Yoav Yinon; Gil S. Epstein; Daniel S. Seidman; Eyal Schiff; Eyal Sivan

doi:10.1055/s-2005-870895

American Journal of Perinatology, Table of Contents

Am J Perinatol 2005; 22(6): 305-309
DOI: 10.1055/s-2005-870895

Insulin-like Growth Factor Binding Protein-1 Detection in Preterm Labor: Evaluation of a Bedside Test

Shai E. Elizur¹ , Yoav Yinon¹ , Gil S. Epstein² , Daniel S. Seidman¹ , Eyal Schiff¹ , Eyal Sivan¹

¹Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine and Tel-Aviv University
²The Department of Economics BAR-Ilan, Ramat Gan, Israel, CEPR, London, and IZA, Bonn, Germany

Abstract

ABSTRACT

Phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) is secreted by decidual cells and may leak into cervical secretions during detachment of the fetal membrane. The aim of this study was to determine whether a rapid bedside test for phIGFBP-1 predicts preterm birth in women with preterm uterine contractions. This was a prospective study of pregnant women who sought medical care for symptoms of preterm labor. Cervical swabs were assayed for the presence of phIGFBP-1 by a rapid bedside test. Sixty-four patients were enrolled. Eleven of them (17%) delivered preterm (< 35 weeks). phIGFBP-1 in cervical secretions predicted preterm birth with a sensitivity of 72.7%, a specificity of 83.0%, a positive predictive value of 47.0%, and negative predictive value of 93.6%. Positive phIGFBP-1 bedside test in women with preterm uterine contractions may indicate a significant risk for subsequent preterm birth. The absence of phIGBP-1 is a reassuring sign that the likelihood of preterm birth is low.

KEYWORDS

phIGFBP-1 - preterm delivery

Full Text

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Shai E ElizurM.D.

Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center

Tel-Hashomer, 52621, Israel