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Semin Neurol 2005; 25(2): 217-228
DOI: 10.1055/s-2005-871330
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Chronic Inflammatory Demyelinating Polyneuropathy and Other Immune-Mediated Demyelinating Neuropathies

Richard A. Lewis1
  • 1Wayne State University School of Medicine, Detroit, Michigan.
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Publication History

Publication Date:
03 June 2005 (online)

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ABSTRACT

The identification of specific disorders caused by immune-mediated attack on Schwann cells and myelin have both improved and confused our understanding and classification of chronic inflammatory and immune-mediated neuropathies. Some investigators consider all neuropathies that respond to immunosuppressive treatment as chronic inflammatory demyelinating polyneuropathy (CIDP), regardless of whether there is evidence for demyelination. Other investigators rely on a very strict definition of CIDP and do not include variations. The goal of this article is to clarify the spectrum of these disorders and provide a logical classification scheme that has clinical utility and yet allows for new information that might distinguish new variations. Therapeutic strategies are also discussed.

KEYWORDS

CIDP (chronic inflammatory demyelinating polyneuropathy) - myelin-associated glycoprotein - CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, IgM paraproteinemia, cold agglutinins, and disialosyl antibodies) - paraprotein - MMN (multifocal motor neuropathy) - Lewis-Sumner syndrome - multifocal acquired demyelinating sensory and motor (neuropathy) - paraprotein - conduction block

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Richard A LewisM.D. 

Department of Neurology, Wayne State University School of Medicine

4201 Saint Antoine Street, Health Center 6E

Detroit, MI 48201-2153