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Synfacts 2005(1): 0098-0098  
DOI: 10.1055/s-2005-872152
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of (+)-trans-195A

Contributor(s): Philip Kocienski, John Cooksey
N. Holub, J. Neidhöfer, S. Blechert*
Technische Universität Berlin, Germany
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Publication History

Publication Date:
21 September 2005 (online)

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Significance

The target molecule is isolated from the species of dendrobatid frog Epipedobates bassier, Dendrobates imitator and Dendrobates variabilis. It is a member of the decahydroquinoline class of alkaloids that exhibit non-competitative blocking of nicotinic receptor channels and inhibitory effects on sodium and potassium transport.