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Synfacts 2005(1): 0092-0092  
DOI: 10.1055/s-2005-872157
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of (+)-Discodermolide via Asymmetric Crotylation

Contributor(s): Philip Kocienski
A. Arefolov, J. S. Panek*
Boston University, USA
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Publication History

Publication Date:
21 September 2005 (online)

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Significance

(+)-Discodermolide is a potent cytotoxic polyketide isolated the rare Caribbean marine sponge Discodermia dissoluta. The molecule exhibits both immunosuppressive and anti-proliferative biological activity and is currently being developed as an anti-cancer drug by Novartis.