A new secoiridoid glycoside characterized as (8Z)-nuezhenide A (1) along with five known glycosides, (8E)-nuezhenide (2), (8Z)-nuezhenide (3), oleonuezhenide (4), osmanthuside B (5) and osmanthuside D (6), were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
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