Three New Agarofuran Sesquiterpenes Reissantins F - H from Reissantia buchananii

Abstract

Three new agarofuran sesquiterpenes, reissantins F - H (1 - 3), were isolated from a methanol extract of Reissantia buchananii. Their structures as well as their relative stereochemistry were established on the basis of modern mass and spectroscopic methods. Compounds 1 - 3 were assayed for cytotoxicity against HepG2 and Hep3B human liver cancer cell lines.

References

• 1 Spivey A C, Weston M, Woodhead S. Celastraceae sesquiterpenoids: biological activity and synthesis.  Chem Soc Rev. 2002;  31 43-59
• 2 Chang F R, Hayashi K, Chen I H, Liaw C C, Bastow K F, Nakanishi Y. et al . Antitumor agents. 228. Five new agarofurans, reissantins A - E, and cytotoxic principles from Reissantia buchananii .  J Nat Prod. 2003;  66 1416-20
• 3 Gamlath C B, Gunatilaka A AL, Schlemper E O. Reissantioloxide: a novel epoxytriterpenoid from Reissantia indica; X-ray crystal structure. J Chem Soc Chem Commun 1988: 249-50
• 4 Gamlath C B, Gunatilaka A AL, Tezuka Y, Kikuchi T. The structure of celastranhydride: a novel triterpene anhydride of Celastraceae.  Tetrahedron Lett. 1988;  29 109-12
• 5 Kuo Y H, Chou C J, Kuo L MY, Hu Y Y, Chen Y C, Chen C F. et al . A sesquiterpene ester from Celastrus hindsii .  Phytochemistry. 1996;  41 549-51
• 6 Furukawa M, Makino M, Uchiyama T, Ishimi K, Ichinohe Y, Fujimoto Y. Sesquiterpene pyridine alkaloids from Hippocratea excelsa .  Phytochemistry. 2002;  59 767-77
• 7 Lan Y H, Chang F R, Liaw C C, Wu C C, Chiang M Y, Wu Y C. Digoniodiol, deoxygoniopypyrone A, and goniofupyrone A: three new styryllactones from Goniothalamus amuyon .  Planta Med. 2005;  71 153-9