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DOI: 10.1055/s-2005-916179
Minor Alkaloids From Guatteria dumetorum with Antileishmanial Activity
Publication History
Received: May 14, 2005
Accepted: July 22, 2005
Publication Date:
05 December 2005 (online)
Abstract
Nine known alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine (3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1 - 4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.
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Dr. Luis Cubilla Rios
Departamento de Química Orgánica
Apdo. 0824 - 10 835
Universidad de Panamá
Panama City
Republic of Panamá
Phone: +507-6681-5371
Fax: +507-264-4450
Email: lucr@ancon. up.ac.pa
- www.thieme-connect.de/ejournals/toc/plantamedica