Planta Med 2006; 72(3): 270-272
DOI: 10.1055/s-2005-916179
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Minor Alkaloids From Guatteria dumetorum with Antileishmanial Activity

Jhonny Edmith Correa1 , Carlos Hernán Ríos1 , Amparo del Rosario Castillo2 , Luz I. Romero2 , Eduardo Ortega-Barría2 , Phyllis D. Coley3 , 4 , Thomas A. Kursar3 , 4 , Maria Verónica Heller4 , William H. Gerwick5 , Luis Cubilla Rios1
  • 1Laboratorio de Bioorgánica Tropical, Universidad de Panamá, República de Panamá
  • 2Instituto de Investigaciones Científicas Avanzadas y Servicios de Alta Tecnología, República de Panamá
  • 3Department of Biology, University of Utah, XXX, Utah, USA
  • 4Instituto Smithsonian de Investigaciones Tropicales, República de Panamá
  • 5College of Pharmacy, Oregon State University, Corvallis, Oregon, USA
Weitere Informationen

Publikationsverlauf

Received: May 14, 2005

Accepted: July 22, 2005

Publikationsdatum:
05. Dezember 2005 (online)

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Abstract

Nine known alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine (3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1 - 4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.

References

Dr. Luis Cubilla Rios

Departamento de Química Orgánica

Apdo. 0824 - 10 835

Universidad de Panamá

Panama City

Republic of Panamá

Telefon: +507-6681-5371

Fax: +507-264-4450

eMail: lucr@ancon. up.ac.pa