Planta Med 2006; 72(4): 300-303
DOI: 10.1055/s-2005-916218
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Antiarrhythmogenic and Antioxidant Effect of the Flavonoid Dioclein in a Model of Cardiac Ischemia/Reperfusion

Heloisa R. Vianna1 , Steyner F. Cortes2 , Anderson J. Ferreira3 , Luciano S. A. Capettini1 , Martine Schmitt4 , Alvair P. Almeida1 , André R. Massensini1 , Virgínia S. Lemos1
  • 1Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • 2Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • 3Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • 4Laboratoire de Pharmacochimie de la Communication Cellulaire, CNRS UMR 7081. Faculté de Pharmacie, Université Louis Pasteur, Illkirch, France
Weitere Informationen

Publikationsverlauf

Received: June 13, 2005

Accepted: September 8, 2005

Publikationsdatum:
20. Januar 2006 (online)

Preview

Abstract

The antiarrhythmogenic effect of the flavonoid dioclein on myocardial ischemia/reperfusion was investigated in isolated perfused rat hearts. Low concentrations of dioclein (30 - 300 nM) induced a reduction of arrhythmias observed during the reperfusion period. Dioclein also preserved the diastolic tension after reperfusion without affecting the systolic tension. In addition, dioclein (150 nM) dramatically reduced the formation of reactive oxygen species (ROS) observed during reperfusion in hearts. In conclusion, dioclein acts as a potent antiarrhythmogenic and antioxidant drug with an excellent protective effect during reperfusion of ischemic hearts.

References

Steyner F. Cortes

Departamento de Farmacologia

Instituto de Ciências Biológicas

Universidade Federal de Minas Gerais

Av. Antonio Carlos

6627 Pampulha

31270-901 Belo Horizonte

MG

Brazil

Telefon: +55-31-3499-2726

Fax: +55-31-3499-2695

eMail: sfcortes@icb.ufmg.br