New Cassaine Diterpenoid Amides with Cytotoxic Activities from the Bark of Erythrophleum fordii

Abstract

A phytochemical investigation of the bark of Erythrophleum fordii led to six new cassaine diterpenoid amides (2, 4 - 8), together with two known compounds of the same skeleton, nor-cassamide (1) and nor-erythrosuamide (3). The structures were mainly established on the basis of 1D, 2D NMR and HR-MS analysis. The compounds 1, 2, 4, 6 - 8 exhibited selective cytotoxic activities (IC₅₀ values < 10 μM) against A2780, KB, Bel-7402, BGC-823, MCF-7, HCT-8, Hela, PC-3M, A549 and Ketr3 human cancer cell lines in the MTT test.

Key words

Erythrophleum fordii - Leguminosae - cassaine diterpenoid amides - cytotoxic activities

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