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Synlett 2005(18): 2837-2842
DOI: 10.1055/s-2005-918919
DOI: 10.1055/s-2005-918919
LETTER
© Georg Thieme Verlag Stuttgart · New York
Lewis Acid Catalyzed Highly Selective Halogenation of Aromatic Compounds
Further Information
Received
7 July 2005
Publication Date:
10 October 2005 (online)
Publication History
Publication Date:
10 October 2005 (online)
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Abstract
A simple and efficient procedure for the halogenation of aromatic compounds with NCS, NBS, NIS and NFSI in the presence of catalytic amount of ZrCl4 is described. Chlorination, bromination, iodination and fluorination of various aromatic compounds are performed with high selectivity under mild reaction conditions.
Key words
halogenation - aromatic compounds - N-halo reagents - zirconium tetrachloride - Lewis acid catalysis
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References
Structure of the product was determined by comparison of 1H NMR and 13C NMR with reported data.