Zusammenfassung
Untersuchungen an depressiven Patienten legen antidepressive Effekte aerober kontinuierlicher körperlicher Aktivität nahe (z.B. Jogging, Walken). Auf der anderen Seite ist bisher ungeklärt, über welche neurobiologischen Mechanismen eine solche Wirkung erzielt wird; humanmedizinische Untersuchungen zu dieser Fragestellung liegen nicht vor. Ergebnisse tierexperimenteller Studien weisen darauf hin, dass körperliche Aktivität u. a. mit einem signifikanten Anstieg zerebraler Monoamine und neurotropher Faktoren (Brain Derived Neurotrophic Factor BDNF) korreliert. Letzteres wiederum bewirkt verstärkte Neurogenese speziell im Hippocampus. In der Grundlagenforschung haben Neurogenese und Neuroplastizität in jüngster Zeit herausragende Bedeutung erlangt. Vielleicht eröffnet die Methode des Dauerleistungstrainings neue therapeutische Optionen nicht nur für depressive Störungen.
Summary
Investigations in depressive patients suggested antidepressive effects of continuous aerobic physical exercise (e.g. jogging, walking). On the other hand, it is yet unclear which mode(s) of neurobiological action are responsible for this since there are no human studies addressing this question. Results of animal studies showed an increase of cerebral monoamines and the Brain Derived Neurotrophic Factor BDNF, which is associated with neuroneogenesis especially in the hippocampus. In today's basic research it has been repeatedly stated that neuroneogenesis and neuroplasticity are of outstanding relevance so that maybe continuous neuromuscular activity opens new therapeutic options not only for depressive disorders.
Key words
physical exercise - depression - cerebral monoamines - neurogenesis
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