Zusammenfassung
Aufgrund starken rezidivierenden Erbrechens und starker Gewichtsabnahme war bei einem 36-jährigen Patienten eine Ösophago-Gastro-Duodenoskopie durchgeführt worden. Diese ergab eine ausgeprägte korpusbetonte Riesenfaltengastritis. Ein malignes Geschehen konnte letztlich mittels Schlingenbiopsie ausgeschlossen werden. Bei initial positivem Urease-Test und positiver H. p.-Serologie wurde trotz negativem histologischen Helicobacternachweis eine Eradikationstherapie nach dem Italian-Triple-Schema durchgeführt. Diese führte zur vollständigen Ausheilung der Riesenfaltengastritis mit kompletter Beschwerdefreiheit des Patienten.
Abstract
Due to permanent vomiting and extreme loss of weight a 36-year-old man got a esophago-gastro-duodenoscopy. The investigastion showed a massive giant fold gastritis mostly in the corpus region. A malignant disease could be excluded with full-thickness mucosal biopsy obtained with a loop. Because of the initially positive reaction of the urease test and the positive serology for Helicobacter pylori an Italian-Triple-Therapy was started to eradicate the H. p. although the Helicobacter could not be found histologically. This therapy lead to the complete remission of the giant fold gastritis and a return to good health.
Schlüsselwörter
Riesenfaltengastritis - Helicobacter pylori - Schlingenbiopsie
Key words
giant fold gastritis - helicobacter pylori - full-thickness mucosal biopsy
Literatur
-
1
Bayerdörffer E, Ritter M, Hatz R, Brooks W, Ruckdeschel G, Stolte M.
Healing of protein losing hypertrophic gastropathy by eradication of Helicobacter pylori - is Helicobacter pylori a pathogenic factor in Ménétrier's disease?.
Gut.
1994;
35
701-704
-
2
Bayerdörffer E, Ritter M, Hatz R, Brooks W, Stolte M.
Ménétrier's disease and Helicobacter pylori.
N Engl J Med.
1993;
329
60
-
3
Burdick J S, Chung E, Tanner G. et al .
Treatment of Ménétrier's disease with a monoclonal antibody against the epidermal growth factor receptor.
N Engl J Med.
2000;
343
1697-1701
-
4
Kindermann A, Koletzko S.
Protein-losing giant fold gastritis in childhood - a case report and differentiation from Ménétrier disease of adulthood.
Z Gastroenterol.
1998;
36
165-171
-
5
Madsen L G, Taskiran M, Madsen J L, Bytzer P.
Ménétrier's disease and Helicobacter pylori: normalization of gastrointestinal protein loss after eradication therapy.
Dig Dis Sci.
1999;
44
2307-2312
-
6
Ménétrier P.
Des polyadénomes gastriques et de leurs rapports avec le cancer de l'estomac.
Arch Physiol Norm Pathol.
1888;
1
32-55
236-262
-
7
Miura S, Asakura H, Tsuchiya M.
Lymphatic abnormalities in protein-losing gastropathy, especially in Ménétrier's disease.
Angiology.
1981;
32
345-354
-
8
Nomura S, Settle S H, Leys C M. et al .
Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression.
Gastronenterology.
2005;
128
1292-1305
-
9
Occena R O, Taylor S F, Robinson C C. et al .
Association of cytomegalievirus with Ménétrier's disease in childhood: Report of two cases with a review of literature.
J Pediatr Gastroenterol Nutr.
1993;
17
217-224
-
10
Odera G, Cinti S, Cangiotti A M. et al .
Increased tight junction width in two children with Ménétrier's disease.
J Pediatr Gastroenterol Nutr.
1990;
11
123-127
-
11
Paciorek M, D'Altorio R, Gleeson G.
Resolution of giant folds after eradication of Helicobacter pylori.
J Clin Gastroenterol.
1997;
25
696-697
-
12 Stolte M. Gastroenterologische Endoskopie und Pathologie - Die wichtigsten Regeln für die endoskopisch-bioptische Diagnostik. In: Classen M, Tytgat GN, Lightdale CJ (Hrsg). Gastroenterologische Endoskopie. Thieme, Stuttgart 2004; 159-176
-
13
Stolte M, Bätz C H, Bayerdörffer E, Eidt S.
Helicobacter pylori eradication in the treatment and differential diagnosis of giant folds in the corpus and fundus of the stomach.
Z Gastroenterol.
1995;
33
198-201
-
14
Stolte M, Bätz C H, Eidt S.
Giant fold gastritis - A special form of Helicobacter pylori associated gastritis.
Z Gastroenterol.
1993;
31
289-293
Prof. Dr. med. B. Kohler
Medizinische Klinik · Fürst-Stirum-Klinik Bruchsal
Gutleutstr. 1-14
76646 Bruchsal
Email: MedKli@Krankenhaus-Bruchsal.de
