RSS-Feed abonnieren
DOI: 10.1055/s-2006-931560
Two New Phthalides from Ligusticum chuanxiong
Publikationsverlauf
Received: October 30, 2005
Accepted: December 15, 2005
Publikationsdatum:
28. April 2006 (online)
Abstract
Two new phthalide dimers, namely chuanxiongnolide A (1) and chuanxiongnolide B (2), along with eleven known phthalides and derivatives (3 - 13), were isolated from the roots of Ligusticum chuanxiong Hort. (Umbelliferae). The chemical structures of the new compounds were established by HR-ESI-MS, 1D- and 2D-NMR spectroscopic analysis, whilst the relative stereochemistry of 1 was confirmed by X-ray crystallographic data.
- Supporting Information for this article is available online at
- Supporting Information .
References
- 1 Chinese Pharmacopoeia Committee. Pharmacopoeia of the People’s Republic of China, Part 1. Beijing; Chemical Industry Press 2005: p 28
- 2 Chen K J, Chen K. Ischemic stroke treated with Ligusticum chuanxiong . Chin Med J. 1992; 105 870-3
- 3 Mourad K, Francine D P, Corjnne P, Albert J C. Three additional phthalide derivatives, an eopxymonomer and two dimmers, from Ligusticum wallichiii rhizomes. J Nat Prod. 1986; 49 872-7
- 4 Takasbi N, Takao K, Kazuaki N. Phthalide dimers from Ligusticum chuanxiong Hort. Heterocycles. 1991; 32 2433-42
- 5 Li S B, Wang Z W, Fang X P, Li Y L. Synthesis of (Z)-ligustilide. Synth Commun. 1993; 23 2909-13
- 6 Beck J J, Stermitz F R. Addition of methyl thioglycolate and benzylamine to (Z)-ligustilide, a bioactive unsaturated lactone constituent of several herbal medicines. An improved synthesis of (Z)-ligustilide. J Nat Prod. 1996; 58 1047-55
- 7 Wang X W. 3-n-Butylphthalide: cerebral antiischemic. Drugs Future. 2003; 25 16-23
- 8 Nagai U, Shishido T, Chiba R, Mrrsuhashi H. Studies on the constituents of Umbelliferae plants. XI. Stereochemistry of 3-butylhydrophthalide. Tetrahedron. 1965; 21 1701-9
- 9 Wang P S, Gao X L, Fu S AB, Guan Y ZD. Studies on chemical constituent of Chinese material medicine Ligusticum chuanxiong . Zhongcaoyao. 1985; 16 137-8
- 10 Mitsuhashi H, Muramatsu T. Studies on the constituents of Umbelliferae plants. VII. Structure of cnidilide and neocnidilide. Tetrahedron. 1964; 20 1971-82
- 11 Mitsuhashi H, Nagai U. Studies on the constituents of Umbelliferae plants. IX. Structure of ligustilide 2. Tetrahedron. 1963; 19 1277-83
- 12 Wang P S, Gao X L, Wang Y X, Yoshiyasu F, Iwao M, Michiharu S. Phthalides from the rhizome of Ligusticum wallichii . Phytochemistry. 1984; 23 2033-8
- 13 Yoshimitsu O, Kunio H, Masao C, Hiroshi M. Synthesis of (-)-3-butyl-4-hydroxyphthalide. Heterocycles. 1989; 29 865-72
- 14 Xiao Y Q, Li L, You X L, Gu K YY, Ma C J. Studies on chemical constituents of the rhizomae of Ligusticum chuanxiong . Zhongguo Zhongyao Zashi. 2002; 27 519-22
- 15 Takashi N, Takao K, Kazuaki N, Yukinobu I, Minoru O, Hiroshi M. Two phthalides from Ligusticum chuanxiong . Phytochemistry. 1992; 31 639-42
- 16 Wen Y S, He Z R, Xue K F, Cao F Y. Studies on chemical constituents of Ligusticum chuanxiong . Zhongcaoyao. 1986; 17 122-126
Li-Sheng Ding
Chengdu Institute of Biology
Chinese Academy of Sciences
Chengdu 610041
People’s Republic of China
Telefon: +86-28-8523-9109
Fax: +86-28-8522-2753
eMail: Isding@cib.ac.cn
- www.thieme-connect.de/ejournals/toc/plantamedica