Félix Calderón* Departamento de Química Orgánica Biológica, Instituto de Química Orgánica General CSIC, C/ Juan de la Cierva 3, Madrid 28006, Spain e-Mail: felix.calderon@iqog.csic.es;
TEMPO (2,2,6,6-Tetramethyl-1-piperidinyloxy radical), as an oxidizing reagent, is the most representative member of the generally called nitroxyl radical oxidant family. They are characterized as weak oxidants that are stable, and soluble in both polar and apolar solvents. However, the radical can be oxidized to form the corresponding oxoammonium salt that is capable of oxidizing many organic functional groups. This oxidized species (Scheme 1) can be generated separately from the reaction mixture or, more interestingly, in situ, allowing a catalytic cycle.
Some reviews can be found in the literature,
[1]
but due to the increasing interest for this family of oxidants, new applications have been published. This Spotlight compiles novel oxidations catalyzed by TEMPO-oxoammonium salt from 2004 to present.
References
1ade Nooy AEJ.
Besemer AC.
van Bekkum H.
Synthesis
1996,
1173
