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Synfacts 2006(7): 0693-0693  
DOI: 10.1055/s-2006-941914
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Self-Assembly of Ligands for Combinatorial Homogeneous Catalysis

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
M. Weis, C. Waloch, W. Seiche, B. Breit*
Albert-Ludwigs-Universität Freiburg, Germany
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Publication History

Publication Date:
22 June 2006 (online)

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Significance

The authors describe the first chiral bidentate phosphorus donor ligand library based on their previously reported hydrogen-bond self-assembly ligands. Many of the combinations provided quantitative conversion, with a subset of these giving very high enantioselectivity (>94% ee). The rhodium-catalyzed hydrogenation of acetamidoacrylate, methyl-α-acetyl-amino cinnamate and dimethylitaconate were all shown to proceed with high conversion and enantioselectivity.