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Osteosynthesis and Trauma Care 2006; 14(3): 181-187
DOI: 10.1055/s-2006-942235
Original Article

© Georg Thieme Verlag Stuttgart · New York

Molecular Biology of Chondrocytes Designed for Transplantation

W. Schlegel1 , C. Albrecht1 , A. Berger1 , S. Nürnberger1 , V. Vécsei1 , S. Marlovits1
  • 1Department for Traumatology, Medical University Vienna, Vienna, Austria
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Publikationsverlauf

Publikationsdatum:
02. November 2006 (online)

    Lizenzen und Reprints

Abstract

Hyaline cartilage is a highly specialised tissue, lacking vascularisation and innervation. Articular cartilage contains a small number of cells compared to the vast amount of extracellular matrix. The smooth surface of articular cartilage is important for frictionless articulation. Degenerative or polytraumatic processes and aging result in inflammation and/or destruction of the intact cartilage layer and have been an unsolved problem so far. Matrix-associated autologous chondrocyte transplantation (MACT) has been introduced as a new option for the biological treatment of patients with focal cartilage defects. To ensure a high quality of the transplants, a consideration of the molecular biological demands on the constructs is indispensable, as cells alter shape and expression patterns during their cultivation period. Real-time PCR is the most powerful tool for this kind of investigation. Additionally, this method allows comparative insights into joint development and regenerative processes.

Key words

cartilage - transplantation - differentiation - development

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Dr. W. Schlegel

Medical University Vienna · Trauma Research Laboratories

Waehringer Guertel 18-20

1090 Vienna

Austria

eMail: werner.schlegel@meduniwien.ac.at