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Synthesis 2006(15): 2603-2607
DOI: 10.1055/s-2006-942470
DOI: 10.1055/s-2006-942470
PAPER
© Georg Thieme Verlag Stuttgart · New York
‘Green’ Iodination of Dimethoxy- and Trimethoxy-Substituted Aromatic Compounds Using an Iodine-Hydrogen Peroxide Combination in Water
Further Information
Received
2 March 2006
Publication Date:
04 July 2006 (online)
Publication History
Publication Date:
04 July 2006 (online)
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Abstract
Mild iodination using iodine and a 30% solution of hydrogen peroxide as oxidant was performed in water. The method proved to be efficient and selective for the introduction of iodine into dimethoxybenzenes, trimethoxybenzenes, and dimethoxy- and trimethoxy-substituted acetophenones, thus significantly contributing toward a more environmentally friendly procedure than that previously reported.
Key words
green chemistry - iodine - halogenation - hydrogen peroxide - iodination in water
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