Ciprofloxacin-induced psychoses have been described in some case reports, occurring sometimes in multi-morbid or personality disordered patients, but also in healthy subjects. We present a case of a 45-year-old man without previous mental disorder, who developed an acute delusional parasitosis after administration of ciprofloxacin. After discontinuation of ciprofloxacin, a complete and sustained remission could be observed within a few days, without the use of any psychopharmacologic medication. Possible modes of action are discussed.
References
1
Abouesh A, Stone C, Hobbs W R.
Antimicrobial-induced mania (anitbiomania): a review of spontaneous reports.
J Clin Psychopharmacol.
2002;
22
71-81
2
Galatti L, Giustini E, Sessa A, Polimeni G, Solvo F, Spina E.
Neuropsychiatric adverse drug reactions in general practice.
Pharmacopsychiatry.
2005;
38
41-68
3 Grimm O, Alm B. A case of ciprofloxacin-induced acute polymorphic psychosis with a distinct deficit of the executive functions. Unpublished preprint 2006; http://cogprints.org/4187/.
4
Hollweg M, Kapfhammer H P, Krupinski M, Möller H J.
Psychopathologische Syndrome unter Behandlung mit Gyrasehemmern.
Nervenarzt.
1997;
68
38-47
9
Rothenhäusler H B, Grieser B, Nollert G, Reichart B, Schelling G, Kapfhammer H P.
Psychiatric and psychosocial outcome of cardiac surgery with cardiopulmonary bypass: a prospective 12-month follow-up study.
Gen Hosp Psychiatry.
2005;
27
18-28
12
Tsuji A, Sato H, Kume Y.
Inhibitory effects of quinolone antibacterial agents on aminobutyric acid binding to receptor sites in rat brain membrane.
Antimicrob Agents Chemother.
1988;
32
190-194