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Planta Med 2006; 72(13): 1238-1241
DOI: 10.1055/s-2006-947196
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Isoquinoline Alkaloids of Different Structural Types on Antiplatelet Aggregation in Vitro

Yi-Chen Chia1 , Fang-Rong Chang2 , Chin-Chung Wu2 , Che-Ming Teng3 , Keh-Shaw Chen1 , Yang-Chang Wu2
  • 1Department of Food Science & Technology, Tajen Institute of Technology, Ping Tung Hsien, Taiwan
  • 2Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 3Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
Further Information

Publication History

Received: December 13, 2005

Accepted: June 1, 2006

Publication Date:
18 September 2006 (online)

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Abstract

Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)-N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5′-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.

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Prof. Dr. Yang-Chang Wu

Graduate Institute of Natural Products

Kaohsiung Medical University

Kaohsiung 807

Taiwan

Republic of China

Phone: +886-7-312-1101-2197

Fax: +886-7-311-4773

Email: yachwu@kmu.edu.tw

    www.thieme-connect.de/ejournals/toc/plantamedica