Sodium Hydrogen Sulfate: Safe and Efficient

Introduction

Although NaHSO₄ has been known for a long time, only in recent years it emerged as an efficient catalyst in or­ganic chemistry. The new interest in this salt is due to ­environmental and economical considerations that prompt urgent need to redesign important chemical processes ­using suitable catalysts. NaHSO₄ can be used alone or supported on alumina [1] or silica gel, in solvent or under solvent-free conditions. The most often used form of it is the silica gel supported form. This catalyst promotes ­various transformations like selective and regioselective protection and deprotection, [2-9] nitration, [10] nitrosation, [11] oxidation, [12] Beckman rearrangement, [1] synthesis of halide derivatives, [13] [14] coupling of indoles, [15] and synthesis of quinazolinones.¹⁶

The advantages of using NaHSO₄ include operational simplicity, selectivity, and availability, and it is inexpensive and ecologically friendly.

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