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Synfacts 2006(9): 0909-0909
DOI: 10.1055/s-2006-949244
DOI: 10.1055/s-2006-949244
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Copper-Catalyzed Synthesis of α,α,α-Trifluoromethylamines
C. Lauzon, A. B. Charette*
Université de Montréal, Canada
Further Information
Publication History
Publication Date:
23 August 2006 (online)
Significance
Diorganozinc additions to aldimines have been extensively studied; however, extension to ketimines is unknown. Here, the authors represent the first example of nucleophilic addition of diorganozinc reagents to ketimines. Using a required precursor to the ketimine, the desired product was formed in high yield and excellent enantioselectivity.