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Synlett 2006(15): 2469-2471  
DOI: 10.1055/s-2006-950437
LETTER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Harounoside, A Naturally Occurring Pentalongin Hydroquinone Bisglucoside

Tuyen Nguyen Vana, Sven Claessensa, Pascal Habonimanaa, Kourosch Abbaspour Tehranib, Luc Van Puyveldea, Norbert De Kimpe*a
a Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
b Department of Organic Chemistry, Faculty of Science, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
Fax: +32(9)2646243; e-Mail: norbert.dekimpe@UGent.be;
Further Information

Publication History

Received 29 June 2006
Publication Date:
08 September 2006 (online)

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Abstract

The recently isolated natural product harounoside, ­namely 5,10-dihydroxy-2H-naphtho[2,3-c]pyran-β-d-bisglucopyranoside, was conveniently synthesized for the first time from pentalongin in 84% yield over three steps.

Key words

natural products - total synthesis - glucosidation

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