Planta Med 2006; 72(14): 1341-1343
DOI: 10.1055/s-2006-951689
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A Novel Isoflavonoid from Millettia puguensis

Modest C. Kapingu1 , Zakaria H. Mbwambo1 , Mainen J. Moshi1 , Joseph J. Magadula1 , Paul Cos2 , Dirk Vanden Berghe2 , Louis Maes3 , Mart Theunis2 , Sandra Apers2 , Luc Pieters2 , Arnold Vlietinck2
  • 1Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
  • 2Department of Pharmaceutical, University of Antwerp, Antwerp, Belgium
  • 3Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
Further Information

Publication History

Received: May 30, 2006

Accepted: August 14, 2006

Publication Date:
20 October 2006 (online)

Abstract

From the roots of Millettia puguensis (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone (4) were isolated and identified by 1H-, 13C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC50 = 32 μM against Leishmania infantum), and a moderate cytotoxicity for compound 2 (IC50 = 43 μM on MRC-5 cells).

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Modest C. Kapingu

Institute of Traditional Medicine

Muhimbili University College of Health Sciences

P.O. Box 65001

Dar es Salaam

Tanzania

Email: mkapingu@muchs.ac.tz