A Novel Isoflavonoid from Millettia puguensis

Modest C. Kapingu; Zakaria H. Mbwambo; Mainen J. Moshi; Joseph J. Magadula; Paul Cos; Dirk Vanden Berghe; Louis Maes; Mart Theunis; Sandra Apers; Luc Pieters; Arnold Vlietinck

doi:10.1055/s-2006-951689

Planta Med 2006; 72(14): 1341-1343
DOI: 10.1055/s-2006-951689

Letter

A Novel Isoflavonoid from Millettia puguensis

Modest C. Kapingu¹ , Zakaria H. Mbwambo¹ , Mainen J. Moshi¹ , Joseph J. Magadula¹ , Paul Cos² , Dirk Vanden Berghe² , Louis Maes³ , Mart Theunis² , Sandra Apers² , Luc Pieters² , Arnold Vlietinck²

¹Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
²Department of Pharmaceutical, University of Antwerp, Antwerp, Belgium
³Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Abstract

From the roots of Millettia puguensis (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone (4) were isolated and identified by ¹H-, ¹³C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC₅₀ = 32 μM against Leishmania infantum), and a moderate cytotoxicity for compound 2 (IC₅₀ = 43 μM on MRC-5 cells).

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References

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Modest C. Kapingu

Institute of Traditional Medicine

Muhimbili University College of Health Sciences

P.O. Box 65001

Dar es Salaam

Tanzania

eMail: mkapingu@muchs.ac.tz