Effects of Catechins on the Mouse Tumor Cell Adhesion to Fibronectin

Kuninori Ogata; Noriyuki Mukae; Yasuo Suzuki; Ken Satoh; Koh Narumi; Toshihiro Nukiwa; Mamoru Isemura

doi:10.1055/s-2006-958140

Planta Medica, Table of Contents

Planta Med 1995; 61(5): 472-474
DOI: 10.1055/s-2006-958140

Letter

Effects of Catechins on the Mouse Tumor Cell Adhesion to Fibronectin

Kuninori Ogata¹ , Noriyuki Mukae¹ , Yasuo Suzuki¹ , Ken Satoh² , Koh Narumi² , Toshihiro Nukiwa² , Mamoru Isemura¹

¹Laboratory of Biochemistry, School of Food and Nutritional Sciences, The University of Shizuoka, Yada, Shizuoka 422, Japan
²Department of Respiratory Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980, Japan

Abstract

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Abstract

We studied the effects of 5 kinds of catechins on the adhesion of mouse lung carcinoma 3LL and melanoma B16F10 cells to the fibronectin substratum. (-)-Epicatechin gallate and (-)-epigallocatechin gallate were active in inhibiting the 3LL cell adhesion, while (+)-catechin, (-)-epicatechin, and (-)-epi-gallocatechin were inactive. Gallate-containing catechins also impaired adhesion and/or spreading of B16F10 cells.

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