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Synthesis 2007(3): 407-411  
DOI: 10.1055/s-2006-958966
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Novel Steroidal Bioconjugates with AZT and Phosphorus

Peiyuan Jina, Kai Liua, Sanhao Jia, Yong Ju*a,b, Yufen Zhaoa
a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China
e-Mail: juyong@tsinghua.edu.cn;
b National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
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Publication History

Received 11 September 2006
Publication Date:
21 December 2006 (online)

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Abstract

Some novel asymmetry steroidal phosphates, phosphorothioates, phosphoroselenoates, and phosphoramidates were synthesized by oxidation or conjugation with amines using the Atherton-Todd reaction. The structures were confirmed by 1H NMR, 31P NMR, and ESI-MS spectroscopy.

Key words

steroidal bioconjugate - AZT - phospholipid - phosphor­amidate