Planta Medica, Table of Contents Planta Med 1991; 57(3): 247-249DOI: 10.1055/s-2006-960083 Papers © Georg Thieme Verlag Stuttgart · New York 6-Pentadecylsalicylic Acid; An Antithrombin Component Isolated from the Stem of Rhus semialata varroxburghii Sheng-Chu Kuo1 , 5 , Che-Ming Teng2 , 5 , Lih-Gen Lee2 , Tai-Hui Chiu1 , Tian-Shung Wu3 , Shung-Chueh Huang1 , Jin-Bin Wu1 , Tiaur-Yarng Shieh1 , Ruey-Ju Chang1 , Teh-Chang Chou4 1Graduate Institute of Pharmaceutical Chemistry, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, Republic of China 2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China 3Department of Chemistry, National Cheng-Kung University, Tainan, Taiwan, Republic of China 4Department of Chemistry, Tunghai University, Taichung, Taiwan, Republic of China 5National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China Recommend Article Abstract PDF Download Buy Article Abstract Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 µg/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction. Key words 6-Pentadecylsalicylic acid - antithrombin - amidolytic method - clotting time - lanatebulic acid - Rhus semialata PDF (209 kb)
