Effects of Chinese Drugs “Xiebai” and “Dasuan” on Human Platelet Aggregation1 (Allium bakeri, A. Sativum)

T. Okuyama; K. Fujita; S. Shibata; M. Hoson; T. Kawada; M. Masaki; N. Yamate

doi:10.1055/s-2006-961993

Planta Medica, Table of Contents

Planta Med 1989; 55(3): 242-244
DOI: 10.1055/s-2006-961993

Papers

Effects of Chinese Drugs “Xiebai” and “Dasuan” on Human Platelet Aggregation¹ (Allium bakeri, A. Sativum)

T. Okuyama² , K. Fujita² , S. Shibata³ , M. Hoson⁴ , T. Kawada⁴ , M. Masaki⁴ , N. Yamate⁴

²Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo 154, Japan
³Laboratory of Natural Medicinal Materials, c/o Minophagen Pharmaceutical Co., Yotsuya 3-2-7, Shinjuku-ku, Tokyo 160, Japan
⁴The Third Department of Surgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki-shi 213, Japan

1 Effect of Oriental Plant Drugs on Platelet Aggregation V. Part IV of this series: Okuyama, T., Takata, M., Shibata, S., Hoson, M., Kawada, T., Masaki, M., Noguchi, T. (1987) Syoyakugaku-Zasshi 41, 147

Abstract

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Abstract

Adenosine (1), guanosine (2), and tryptophan (3), as well as (β-sitosterol (β-D-glucoside (4) were isolated from the n-butanol-soluble fraction of Xiebai, the tuber of Allium bakeri Reg., which was recognized to have an anti-platelet aggregation effect. Moreover, 1 and 2 were also isolated from the n-butanol-soluble fraction of Dasuan, the tuber of A. sativum L. Compound 1 showed a significant inhibitory activity against both the primary and secondary wave aggregation of human platelet induced by 2 µM ADP, whereas compounds 2-4 showed no or very low inhibitory effects. The structure-activity relationships on human platelet aggregation with regard to 1, 2 and their derivatives, adenosine 2′-monophosphate (5), adenosine 5′-monophosphate (6), adenosine triphosphate (7), guanosine 3′-monophosphate (8), and guanosine 5′-monophosphate (9), and guanylyl(3′→5′)adenosine (10) are discussed. Compounds 5-7 and 10 also inhibited the primary and secondary wave aggregation with a dose-dependent response.

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