Adventures in Inner Space: Microflow Systems for Practical Organic Synthesis

Abstract

This account presents an overview of our recent endeavors to achieve practical organic syntheses using a variety of microreaction devices. Herein are our achievements in ionic liquid-based catalytic reactions, photochemical transformation, and heterogenous hydrogenation reactions, where flow regime precisely controls residence time and product selectivity.

1 Introduction

2 Cross-Coupling Reactions Using Ionic Liquids and Microflow Systems

2.1 The Sonogashira Coupling Reaction in a Microreaction System

2.2 The Mizoroki-Heck Reaction in an Automated Microflow Production System

2.3 Carbonylation in an Ionic Liquid and Application to a Microflow System

3 Photo- and Radical Reactions in a Microflow System

4 Gas-Liquid-Solid Triphasic Catalytic Reactions in a Microflow System

5 Conclusion

Key words

microreactor - cross-coupling reaction - carbonylation - hydrogenation - photoreaction - ionic liquid - continuous production system

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16

Manuscript in preparation.

32

The photomicroreactor, Mikroglas Dwell Device, was purchased from Mikroglas Chemtech GmbH. FOTURAN^® glass allows light with λ > 250 nm to be transmitted.

36

The photomicroreactor was generously provided by Dainippon Screen Mfg. Co., Ltd.

39

The MiChS micromixer (type-α) was obtained from MiChS Co. Ltd., Japan.

40

Fukuyama, T.; Kobayashi, M.; Rahman, M. T.; Kamata, N.; Ryu, I. to be published.

47

Yoswathananont, N.; Nitta, K.; Mima, J.; Sato, M. to be published.